上海塔望 小動物呼吸功能監測系統 WBP
TOW-INT 全身體積描記系統(Whole-body Plethysmograph,WBP),可用於測量清醒且自由活動動物的呼吸參數,例如呼吸頻率、潮氣量、氣道高反應性(Airway Hyperresponsiveness,AHR)等。測試過程中,動物處於清醒自由的狀態,無需進行創傷性的氣管切開或使用麻醉,從而避免相關干擾,使實驗更加簡便。該系統適用於呼吸系統模型動物對藥物反應的研究,以及呼吸性藥物的藥理學與毒理學評估,適合進行大量動物的快速初步篩選試驗,以及長期追蹤研究及重複性篩查。
TOW-INT 全身體積描記系統 WBP

產品特點
- 無須手術
- 多通道同步監測
- 自然狀態下呼吸研究
- 適合連續監控
- 配備氣溶膠霧化模組
- 內件分析軟體
擴展應用
- 光遺傳/ EEG/ 電生理實驗
- 影像監測
- 吸入式毒理
- 咳嗽監測
- 持續注射給藥、微透析
- 高氧/ 低氧研究
- 動物活動量監測

相關文獻
[1] Zhou J W, Bai Y, Guo J Q, et al. Peroxiredoxin 4 as a switch regulating PTEN/AKT axis in alveolar macrophages activation[J]. Signal Transduction and Targeted Therapy (IF 52.7), 2025, 10(1): 352.
[3] Wang Z, Miao Z, Cao Z, et al. Mild Hyperthermia‐Assisted Coaxial Electrospun Nanofiber Patches for Epicutaneous Allergen‐Specific Immunotherapy[J]. Advanced Functional Materials (IF 19.0), 2025: e09955.
[5] Chen J, Wang J, Zheng W, et al. Brain–cervical lymph node crosstalk contributes to brain injury induced by subarachnoid hemorrhage in mice[J]. Nature Communications (IF 15.7), 2025, 16(1): 8551.
[7] Wang Z, Lu X, Wu L, et al. Co-delivery of targeted hypoallergens and resiquimod powders using silk fibroin microneedles for effective allergen-specific immunotherapy[J]. Theranostics (IF 13.3), 2025, 15(16): 8096.
[9] Li H, Liu S, Dai W, et al. Pressure-sensitive multivesicular liposomes as a smart drug-delivery system for high-altitude pulmonary edema[J]. Journal of Controlled Release (IF 11.5), 2024, 365: 301-316.
[11] Luo L, Qin Z, Chen M, et al. γ-Aminobutyric acid–mediated parafacial zone: Integrating consciousness and respiratory control in sevoflurane anesthesia[J]. Anesthesiology (IF 9.1), 2025, 144(1): 116.
[13] Wei X, Cao X, Xu C, et al. Revolutionizing antibiotic therapy: polymyxin B and Fe2+-enriched liposomal carrier harness novel bacterial ferroptosis mechanism to combat resistant infections[J]. Journal of Pharmaceutical Analysis, 2025: 101293.
[15] Liu J, Gao J, Xiong A, et al. Exploring Cistanche's therapeutic potential and molecular mechanisms in asthma treatment[J]. Phytomedicine, 2025, 136: 156265.
[17] Jiang J, Ai S, Yuan C, et al. Dysfunction of cholinergic neuron in nucleus ambiguous aggravates sepsis-induced lung injury via a GluA1-dependment mechanism[J]. Brain, Behavior, and Immunity, 2025.
[19] Su J, Tu Y, Hu X, et al. Ambient PM2. 5 orchestrates M1 polarization of alveolar macrophages via activating glutaminase 1-mediated glutaminolysis in acute lung injury[J]. Environmental Pollution, 2025, 366: 125467.
[21] Zhang M, Xu B, Li N, et al. All-Hydrocarbon Stapled Peptide Multifunctional Agonists at Opioid and Neuropeptide FF Receptors: Highly Potent, Long-Lasting Brain Permeant Analgesics with Diminished Side Effects[J]. Journal of Medicinal Chemistry, 2023.
[23] Wang Y, Liu X, Zhang Q, et al. Bioluminescence-optogenetics-mediated gene therapy in a sleep-disordered breathing mouse model[J]. Biomedicine & Pharmacotherapy, 2024, 178: 117159.
[25] Jiang Y, Zhang Y, Wang X, et al. Phosphatase PHLPP1 is an alveolar-macrophage-intrinsic transcriptional checkpoint controlling pulmonary fibrosis[J]. Cell Reports, 2025, 44(3).
[27] Jin M, Liu J, Shao M, et al. Chitosan Nanoparticles for Pulmonary Delivery of Curcumin/Nintedanib to Treat Pulmonary Fibrosis[J]. International Journal of Nanomedicine, 2025: 12959-12973.
[29] Jia X, Liu S, Sun C, et al. METTL16 controls airway inflammations in smoking-induced COPD via regulating glutamine metabolism[J]. Ecotoxicology and Environmental Safety, 2025, 289: 117518.
[31] Li Q, Ang Y, Zhou Q, et al. Coral calcium hydride promotes peripheral mitochondrial division and reduces AT-II cells damage in ARDS via activation of the Trx2/Myo19/Drp1 pathway[J]. Journal of Pharmaceutical Analysis, 2024: 101039.
[33] Akhtemova N, Sergazina A, Bolatbekov T, et al. The role of major allergens Art v 1 and Art v 3 in Artemisia pollen-induced asthma: a mouse model study[J]. Frontiers in Immunology, 2025, 16: 1590791.
[35] Zhang Y, Jiang M, Xiong Y, et al. Integrated analysis of ATAC-seq and RNA-seq unveils the role of ferroptosis in PM2. 5-induced asthma exacerbation[J]. International Immunopharmacology, 2023, 125: 111209.
[37] Lin Y, Wu Y, Ma F, et al. Exploration of the mechanism of Qi-Xian decoction in asthmatic mice using metabolomics combined with network pharmacology[J]. Frontiers in Molecular Biosciences, 2023, 10.
[39] Zhang Y, Yang Y, Liang H, et al. Nobiletin, as a Novel PDE4B Inhibitor, Alleviates Asthma Symptoms by Activating the cAMP-PKA-CREB Signaling Pathway[J]. International Journal of Molecular Sciences, 2024, 25(19): 10406.
[41] Ma J, Ni Z, Chen Q, et al. Exploring the kidney-tonifying effect of Qi-Xian decoction for asthma treatment by modulating the proliferation and migration of endogenous BMSCs[J]. Chinese Journal of Natural Medicines, 2025, 23(12): 100009.
[43] Yuan Z, Wang Q, Tan Y, et al. Methylprednisolone alleviates lung injury in sepsis by regulating miR-151-5p/USP38 pathway[J]. International Immunopharmacology, 2024, 138: 112548.
[45] He J, Li J, Lin Q, et al. Anti-CD20 treatment attenuates Th2 cell responses: implications for the role of lung follicular mature B cells in the asthmatic mice[J]. Inflammation Research, 2024, 73(3): 433-446
[47] Chen N, Xie Q M, Song S M, et al. Dexamethasone protects against asthma via regulating Hif-1α-glycolysis-lactate axis and protein lactylation[J]. International Immunopharmacology, 2024, 131: 111791.
[49] Wei M, Song M, Lin L, et al. Mechanism of Keke tablets in treating post-infectious cough following influenza A virus infection based on network pharmacology, molecular docking, molecular dynamics and in vivo experiments[J]. International Immunopharmacology, 2025, 162: 115123.
<p style="margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: inherit; font-family: " pingfang="" sc",="" "hiragino="" sans="" gb",="" "microsoft="" yahei="" ui",="" yahei",="" "source="" han="" cn",="" sans-serif;="" font-optical-sizing:="" inherit;="" font-size-adjust:="" font-kerning:="" font-feature-settings:="" font-variation-settings:="" font-language-override:="" vertical-align:="" baseline;="" text-align:="" justify;"="">[50] Gong X T, Li Z S, Chen Z L, et al. Basal forebrain-ventral tegmental area glutamatergic pathway promotes emergence from isoflurane anesthesia in mice[J]. Journal of Neuroscience, 2025.